Ingredients: High Purity Fisetin Powder - 100%

We provide pure unadulterated single ingredient supplements to ensure our customers can maintain complete control over what they consume.

Be advised, Fisetin is a flavanoid with a strong bitter taste. Due to the high purity of this ingredient the bitter taste is extreme.

Fisetin is a natural antioxidant, anti-inflammatory flavonoid, and senolytic compound that offers a range of potential health benefits:

1. Senolytic Properties (Cellular Rejuvenation)
   Fisetin is considered a senolytic, meaning it may help promote the clearance of senescent cells—cells that have become damaged or dysfunctional over time. By removing these cells, fisetin could help support overall cellular rejuvenation, potentially contributing to healthier tissue function and slowing the effects of aging.
2. Supports Cognitive Function
   Fisetin has antioxidant properties that may help protect brain cells from oxidative stress. It also supports neurogenesis (the growth of new neurons), which could contribute to improved memory and cognitive function as part of healthy aging.
3. Antioxidant Protection
   As a potent antioxidant, fisetin helps neutralize free radicals, which are unstable molecules that can damage cells. This antioxidant activity may support general health and help protect cells from oxidative stress.
4. Anti-Inflammatory Effects
   Fisetin may help reduce inflammation in the body, which is linked to various health concerns. Its anti-inflammatory properties could support overall wellness by helping to maintain a more balanced inflammatory response.
5. Supports Healthy Aging
   By promoting cellular repair and protecting against oxidative damage, fisetin may help support healthy aging. It works by reducing oxidative stress and supporting tissue regeneration, helping to maintain the health of cells and tissues over time.
6. Improves Skin Health
   The antioxidant and anti-inflammatory properties of fisetin may benefit the skin by protecting it from UV-induced damage and oxidative stress, which can contribute to the appearance of fine lines and wrinkles.
7. Supports Heart Health
   Fisetin’s antioxidant and anti-inflammatory effects may support heart health by helping to maintain better circulation and vascular function, potentially contributing to overall cardiovascular wellness.
8. Promotes Metabolic Health
   Fisetin may support metabolic function, potentially helping to maintain healthy blood sugar levels and insulin sensitivity, which are important aspects of general metabolic health.

In summary, fisetin offers potential benefits by supporting cellular rejuvenation, protecting against oxidative stress, reducing inflammation, and supporting overall wellness. Its senolytic properties and antioxidant activity make it a valuable addition to a health-focused lifestyle, particularly in the context of healthy aging and cognitive support.

Fisetin works through several biological mechanisms to provide its health benefits, targeting specific receptors and pathways in the body:

1. Senolytic Action (Clearing Senescent Cells)
   One of the key mechanisms of fisetin is its senolytic action. Fisetin selectively targets senescent cells—cells that have stopped dividing and accumulate as we age. These cells are linked to chronic inflammation and tissue degeneration. Fisetin helps clear these senescent cells by activating certain cell death pathways (such as apoptosis) that eliminate these damaged cells from the body. This reduces inflammation, promotes tissue repair, and may contribute to healthier aging.
2. Antioxidant Mechanism (Reducing Oxidative Stress)
   Fisetin acts as a potent antioxidant, neutralizing reactive oxygen species (ROS) or free radicals. ROS are by-products of normal cellular processes but can accumulate in excess due to stress, poor diet, and aging, leading to oxidative damage. Fisetin helps reduce this damage by scavenging free radicals and upregulating the body’s natural antioxidant enzymes, such as superoxide dismutase (SOD) and catalase. This supports cellular integrity, especially in aging cells that are more vulnerable to oxidative damage.
3. Anti-Inflammatory Pathways
   Fisetin helps modulate the body’s inflammatory response by inhibiting key molecules involved in inflammation. It can reduce the activity of NF-kB (Nuclear Factor kappa-light-chain-enhancer of activated B cells), a protein complex that controls the transcription of inflammatory genes. By downregulating pro-inflammatory cytokines (such as IL-6 and TNF-alpha), fisetin helps to reduce chronic inflammation, which is associated with numerous age-related conditions.
4. Neuroprotective Mechanisms (Supporting Brain Health)
   Fisetin promotes neurogenesis (the formation of new neurons) in the brain by activating the BDNF (Brain-Derived Neurotrophic Factor) pathway. BDNF is essential for neural plasticity—the ability of the brain to reorganize and form new connections. Fisetin’s antioxidant effects also protect neurons from oxidative damage, preventing neuronal death and supporting cognitive function. In addition, fisetin may enhance synaptic plasticity, improving memory and learning by ensuring the healthy functioning of neural networks.
5. Metabolic Regulation
   Fisetin helps support metabolic health by improving insulin sensitivity. It activates the AMP-activated protein kinase (AMPK) pathway, which plays a key role in regulating energy balance and glucose metabolism. AMPK helps to reduce blood sugar levels by increasing glucose uptake in muscle cells and promoting the breakdown of fat stores for energy. This makes fisetin beneficial for maintaining healthy metabolic function.
6. Skin Protection Mechanisms
   Fisetin also supports skin health by reducing UV-induced oxidative stress. It inhibits the activation of inflammatory pathways triggered by UV exposure, such as the MAPK (mitogen-activated protein kinase) signaling pathway, which can lead to skin damage and premature aging. By reducing oxidative stress and inflammation, fisetin helps prevent photoaging and supports the repair of damaged skin cells.

In summary, fisetin works through a range of mechanisms: it acts as a senolytic to clear aging cells, antioxidant to protect against oxidative stress, anti-inflammatory to modulate inflammation, and neuroprotective to support cognitive function. These actions contribute to its broad health benefits, supporting healthy aging, brain health, metabolic function, and skin integrity.

Taste Warning
Fisetin has an extremely bitter flavor, especially at higher doses. To make it more tolerable, we strongly recommend mixing it with strong flavors. Add it to smoothies with citrus or berries, or mix it into strong teas like ginger or peppermint. Using honey or other sweeteners can also help mask the bitterness.

Dose Ranges for Different Goals
The optimal dosage of fisetin can vary depending on your specific health goals:

• For General Health and Antioxidant Support: A typical dose is 100mg to 200mg per day. This supports overall health by reducing oxidative stress and promoting healthy aging.
• For Cognitive Function and Brain Health: A dose of 200mg to 300mg per day can help protect brain cells, improve memory and focus, and support overall cognitive function.
• For Metabolic Health and Inflammation: A range of 200mg to 300mg per day can help support metabolic function and reduce inflammation.
• For Senolytic Regimen (Cellular Rejuvenation): For a senolytic regimen, higher doses are used for short periods to clear senescent cells. A typical dosage is 1,000mg (1g) per day for 2–3 days, followed by a break. This burst dosing helps target aging cells and promote rejuvenation.

Warnings for Senolytic Regimen

• Short-Term Use Only: For senolytic action, fisetin should only be taken in high doses for 2–3 days in a row, followed by a break. Prolonged use of high doses is not recommended.
• Consult a Healthcare Professional: Because of the high doses involved in a senolytic regimen, it’s advisable to consult with a healthcare provider before starting, particularly for those with existing health conditions or concerns.

Solubility
Fisetin is fat-soluble, meaning it’s best absorbed when taken with healthy fats. Mix fisetin powder into a smoothie, tea, or shake containing coconut oil, avocado, or MCT oil for improved absorption.

In summary, fisetin can be taken in different dose ranges depending on your goals, with typical doses ranging from 100mg to 300mg per day for general health, brain function, and metabolic support. For a senolytic regimen, higher doses of 1,000mg per day for 2-3 days are recommended to target senescent cells, followed by a break. Always mix fisetin with healthy fats for better absorption and be mindful of its bitter taste, which can be masked with strong, flavorful ingredients. If using fisetin for a senolytic regimen, please use only as directed and consult with a healthcare professional beforehand.

To maintain the potency of your Pure Fisetin Powder, store it in a cool, dry place, away from direct sunlight, heat, and moisture. Keep the resealable pouch fully sealed to protect it from air and moisture. Always ensure the pouch is tightly closed after each use to preserve the powder’s quality.