Mito-Boost - Ingredients (mg/scoop)

β-Nicotinamide Mononucleotide (NMN): 495.0 mg
Medium Chain Triglycerides (Coconut, Organic): 465.3 mg
Trans-Resveratrol: 300.0 mg
Tri-Methyl Glycine (TMG): 275.0 mg
Spermidine: 5.5 mg
Piperine (Black Pepper Extract): 3.8 mg

Quantities based on a level scoop.

The provided scoop holds approximately 1.5g of the Mito-Boost formulation.

Allergens: May contain traces of MILK

MitoBoost is a comprehensive formulation that merges science-backed ingredients to support overall vitality, healthy aging, and cellular function. By working in concert, these components promote optimal energy production, enhanced cognitive function, and robust mitochondrial health—all crucial factors in maintaining longevity. Below is an overview of each ingredient’s benefits and the ways in which they complement each other.

β-Nicotinamide Mononucleotide (NMN)

NMN is a key precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme essential for energy metabolism, DNA repair, and healthy cellular processes. By boosting NAD+ levels, NMN supports mitochondrial function and promotes overall cellular energy [1,2]. This enhancement of mitochondrial activity contributes to healthy aging and longevity.

Trans-Resveratrol

Resveratrol is a potent antioxidant recognized for its capacity to activate sirtuin pathways—proteins linked to longevity and metabolic regulation. By mitigating oxidative stress and helping support cardiovascular well-being, Resveratrol can mimic certain beneficial effects of caloric restriction [3,4]. When paired with NMN, the synergy between elevated NAD+ levels and sirtuin activation may optimize cellular health and resilience.

Tri-Methyl Glycine (TMG)

TMG plays a vital role in methylation—a biochemical process important for maintaining DNA integrity, detoxification, and balanced bodily functions. By supporting methylation, TMG helps preserve healthy liver function and assists in regulating homocysteine levels [5]. In the context of MitoBoost, TMG’s contribution can complement both NMN (energy metabolism) and Resveratrol (antioxidant protection).

Spermidine

Spermidine is linked to autophagy, the body’s mechanism for removing damaged cells and generating new ones. This cellular “renewal” process can contribute to longevity by clearing out dysfunctional organelles and proteins [6]. Together with NAD+-supporting NMN and Resveratrol’s antioxidant defense, Spermidine helps maintain healthier cells over time.

Piperine (Black Pepper Extract)

Piperine improves the bioavailability of various nutrients, especially Resveratrol, ensuring they are efficiently absorbed and utilized [7]. By enhancing the uptake of these active components, Piperine helps maximize the overall effectiveness of MitoBoost’s ingredients.

Medium Chain Triglycerides (MCTs)

MCTs are critical for the solubility of fat-soluble molecules like Resveratrol, aiding in their proper absorption and utilization [8]. They also offer a readily available energy source, supporting metabolic health and potentially contributing to weight management. By facilitating Resveratrol’s absorption, MCTs help ensure that each dose of MitoBoost delivers its full potential.

In summary, MitoBoost’s blend of NMN, Resveratrol, TMG, Spermidine, Piperine, and MCTs provides layered benefits that address mitochondrial function, energy production, antioxidant defense, cellular detoxification, and metabolic support. By working synergistically, these ingredients promote a holistic approach to healthy aging, cognitive function, and overall vitality.

MitoBoost: Mechanism of Action and Synergy

Peak Bio-Tech's MitoBoost formulation combines specific ingredients—NMN, Resveratrol, TMG, Spermidine, Piperine, and MCTs—to target complementary pathways that enhance cellular function, mitochondrial health, and overall vitality. By focusing on both the production and efficient use of energy, this synergistic approach helps support healthy aging, metabolic balance, and cognitive performance.

1. β-Nicotinamide Mononucleotide (NMN)
NMN is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), an essential coenzyme for energy metabolism in mitochondria [1,2]. NAD+ not only fuels ATP production but also activates sirtuins—proteins involved in longevity, DNA repair, and metabolic regulation.

- Key Mechanism: By increasing NAD+ levels, NMN helps ensure sirtuins and other NAD+-dependent enzymes can function effectively, promoting mitochondrial health and supporting normal cellular aging processes [9].

2. Trans-Resveratrol
Resveratrol acts on the sirtuin pathway in a manner complementary to NMN. While NMN increases the availability of NAD+ (the “fuel”), Resveratrol effectively acts as an “accelerator” by further stimulating sirtuin activity [3,4]. It has also been shown to influence AMPK (AMP-activated protein kinase), a sensor of cellular energy status [10].

- Key Mechanism: Through antioxidant activity and metabolic modulation, Resveratrol helps protect mitochondria from oxidative damage and promotes efficient energy utilization, thereby reinforcing the benefits of NAD+ elevation.

3. Tri-Methyl Glycine (TMG)
With NMN boosting NAD+ and amplifying various cellular processes, TMG supplies methyl groups for methylation—crucial for DNA integrity, detoxification, and balanced gene expression [5].

- Key Mechanism: Proper methylation ensures the cell can handle the increased biochemical demands from enhanced NAD+ metabolism, maintaining healthy gene regulation and supporting liver function.

4. Spermidine
Spermidine is associated with autophagy, the cell’s method of clearing damaged components and promoting regeneration [6]. This process also helps remove dysfunctional mitochondria, facilitating the replacement of older organelles with healthier ones.

- Key Mechanism: Spermidine-driven autophagy complements NAD+ and sirtuin support by promoting a “cellular cleanup,” which can improve overall mitochondrial quality and efficiency.

5. Piperine (Black Pepper Extract)
Piperine aids in the absorption of Resveratrol and other nutrients [7]. By slowing metabolic breakdown and enhancing intestinal uptake, it maximizes the impact of Resveratrol’s antioxidant and sirtuin-activating properties.

- Key Mechanism: Improved bioavailability ensures that all active compounds reach target tissues more effectively, increasing the synergy between NAD+ boosters and sirtuin activators.

6. Medium Chain Triglycerides (MCTs)
Resveratrol is fat-soluble and requires lipids for optimal absorption. MCTs not only help solubilize Resveratrol, they also provide a rapid energy source that is readily metabolized by the liver into ketones [8].

- Key Mechanism: MCTs support both nutrient bioavailability and metabolic flexibility, supplying additional energy that can complement mitochondrial function enhanced by NMN.

Putting It All Together
1. NMN elevates NAD+ levels, fueling sirtuin activity.
2. Resveratrol amplifies sirtuin function and influences AMPK, further boosting energy regulation.
3. TMG ensures robust methylation to keep up with heightened cellular demands.
4. Spermidine promotes autophagy, helping remove damaged mitochondria and cells.
5. Piperine increases the absorption of key ingredients, especially Resveratrol.
6. MCTs aid in the solubilization of Resveratrol and provide quick energy.

Through these complementary mechanisms, MitoBoost supports mitochondrial function, bolsters energy production, and fosters longevity pathways—all while remaining accessible to individuals seeking to optimize cognitive function, metabolic health, and overall cellular well-being.

For optimal results, we recommend taking 1 to 2 scoops per day of MitoBoost. Here's how you can take it:

1. Dosage: Start with 1 scoop (per day) to assess your body’s response. You can increase to 2 scoops per day based on your needs and desired benefits.
2. Mixing: Mix the powder with a drop of water and stir thoroughly to ensure it dissolves properly. You can also adjust the water amount to your preference, but a small amount is ideal to aid in absorption.
3. When to take: It’s best to take MitoBoost in the morning or early afternoon to support energy levels throughout the day, but it can also be taken at any time that works best for you.

In summary, take 1 to 2 scoops per day, mix with a drop of water, and consume to support your mitochondrial health, energy production, and overall vitality.

To preserve the quality and potency of MitoBoost, store it in a cool, dry place, away from direct sunlight, heat, and moisture. The NMN in this formula is temperature-stabilized, so there is no need to refrigerate it. However, if you prefer, you can store it in the fridge, but be sure that the resealable pouch is fully sealed to prevent moisture from affecting the powder. Always ensure the pouch is tightly closed after each use to maintain the freshness and effectiveness of the powder.

References
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[2] Cantó C, Menzies KJ, Auwerx J. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab. 2015;22(1):31-53. doi: 10.1016/j.cmet.2015.05.023
[3] Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493-506. doi: 10.1038/nrd2060
[4] Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425(6954):191-196. doi: 10.1038/nature01960
[5] Wang Z, Yao T, Song Z. Trimethylglycine supplementation protects against alcohol-induced liver steatosis in mice by improving very low-density lipoprotein secretion. FEBS J. 2010;277(21):4644-4654. doi: 10.1111/j.1742-4658.2010.07846.x
[6] Eisenberg T, Knauer H, Schauer A, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009;11(11):1305-1314. doi: 10.1038/ncb1975
[7] Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-356. doi: 10.1055/s-2006-957450
[8] Van Wymelbeke V, Himaya A, Louis-Sylvestre J, Fantino M. Influence of medium-chain and long-chain triacylglycerols on the control of food intake in men. Am J Clin Nutr. 1998;68(2):226-234. doi: 10.1093/ajcn/68.2.226
[9] Fang EF, Hou Y, Lautrup S, et al. NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nat Commun. 2019;10(1):5284. doi: 10.1038/s41467-019-13172-8
[10] Zang M, Xu S, Maitland-Toolan KA, et al. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor–deficient mice. J Biol Chem. 2006;281(46):35404-35417. doi: 10.1074/jbc.M603511200