Ingredients: Trimethylglycine (TMG) - 100%

TMG (Trimethylglycine), also known as betaine, is a naturally occurring compound that plays a key role in supporting methylation processes in the body. It offers several health benefits, particularly when paired with NMN (Nicotinamide Mononucleotide) to enhance its effects. Here’s a breakdown of the key benefits of TMG:

1. Supports Methylation
   TMG is a powerful methyl donor, which means it helps supply the necessary methyl groups required for various critical processes in the body, including DNA repair, gene expression, and the synthesis of neurotransmitters. Proper methylation is essential for overall health, and TMG helps ensure that these processes function efficiently.
2. Works Synergistically with NMN
   TMG is particularly beneficial when taken alongside NMN, as NMN increases cellular activity by boosting NAD+ levels. This heightened cellular activity can increase the demand for methylation, and TMG helps provide the necessary methyl groups to support this process, ensuring the body can fully benefit from the increased NAD+ levels provided by NMN.
3. Supports Liver Health
   TMG has been shown to promote liver health by supporting the detoxification processes in the body. It helps reduce the accumulation of fat in the liver, which can improve liver function and overall metabolic health.
4. Improves Cardiovascular Health
   TMG has been linked to improved cardiovascular health by helping to lower homocysteine levels. High homocysteine is a risk factor for cardiovascular disease, and by converting it into less harmful substances, TMG helps support heart health.
5. Enhances Physical Performance
   TMG plays a role in supporting muscle function and endurance. It helps improve the body’s ability to utilize amino acids, which are essential for muscle recovery and performance, making it beneficial for overall physical performance.
6. Promotes Healthy Aging
   By supporting methylation and promoting cellular repair, TMG can contribute to healthy aging. Proper methylation is crucial for maintaining cellular integrity and DNA stability, which can help reduce the impact of age-related cellular decline.

In summary, TMG offers a variety of health benefits, from supporting methylation and liver health to improving cardiovascular function and enhancing physical performance. When paired with NMN, TMG ensures that the body can fully take advantage of increased NAD+ levels by providing the necessary methyl groups to support enhanced cellular activity and healthy aging.

TMG (Trimethylglycine) functions primarily as a methyl donor, supporting key biochemical processes, particularly methylation, which is essential for maintaining proper cellular function. Here’s a deeper dive into the technical mechanisms of how TMG works in the body:

1. Methylation and Epigenetic Regulation
   Methylation is a fundamental biochemical process where methyl groups (–CH3) are transferred to DNA, proteins, and lipids. This regulates gene expression, ensuring that the right genes are activated or silenced at the right time. TMG donates methyl groups that are crucial for this process. When methylation occurs, it modulates DNA accessibility, allowing proteins and enzymes to either repair or regulate genes and their expression. Proper methylation is key to cellular maintenance, DNA stability, and the repair of damaged DNA.
2. Supporting the One-Carbon Metabolism Pathway
   TMG plays an essential role in the one-carbon metabolism pathway, which is responsible for maintaining the balance of methyl groups in the body. In this pathway, TMG donates a methyl group to convert homocysteine into methionine, an amino acid required for the synthesis of SAMe (S-adenosylmethionine). SAMe is a critical compound involved in many methylation reactions and serves as a precursor for other important molecules, including neurotransmitters. By enhancing the one-carbon cycle, TMG helps maintain an optimal methylation environment, which supports overall cellular function.
3. Homocysteine Regulation
   TMG's impact on homocysteine metabolism is significant for both cardiovascular health and cellular stability. High levels of homocysteine are toxic to cells and tissues, particularly in the vascular system, where they contribute to oxidative stress and endothelial damage. TMG helps convert excess homocysteine into methionine, reducing the risk of cardiovascular conditions related to high homocysteine levels, such as atherosclerosis. This also reduces the oxidative burden on cells, supporting cellular integrity and reducing systemic inflammation.
4. Synergy with NMN in Cellular Energy
   When combined with NMN (Nicotinamide Mononucleotide), TMG plays a crucial role in optimizing the methylation process that supports the increased cellular activity driven by NMN’s NAD+ boost. As NMN elevates NAD+ levels, it stimulates sirtuins and other metabolic enzymes that increase energy production, DNA repair, and mitochondrial function. Since this increased cellular activity demands more methylation to maintain gene expression and DNA integrity, TMG ensures that adequate methyl groups are available to support these processes, enhancing the effectiveness of NMN.
5. Improving Amino Acid and Protein Metabolism
   TMG plays a role in amino acid metabolism, particularly in the synthesis of methionine, which is involved in protein synthesis and the formation of other critical compounds like glutathione. Glutathione is a powerful antioxidant that helps protect cells from oxidative damage and supports the immune system. By supporting protein synthesis and reducing oxidative damage, TMG enhances muscle function, physical performance, and recovery after exertion.

In summary, TMG works as a methyl donor, supporting methylation processes that regulate gene expression, DNA repair, and cellular function. By participating in the one-carbon metabolism pathway, TMG helps regulate homocysteine levels, promoting cardiovascular health and reducing oxidative stress. Additionally, it ensures that the body has the necessary methyl groups to fully support the increased cellular activity generated by NMN, optimizing energy production and overall well-being. Through these mechanisms, TMG plays a vital role in maintaining cellular stability and promoting healthy aging.

For optimal results, we suggest taking 1 to 2 scoops per day of TMG, with each level scoop containing approximately 590mg of TMG. This dosage falls within typical use ranges for TMG supplementation, but individual needs may vary. Here's how you can approach your dosage:

1. Starting Dosage
   It’s advisable to start with 1 scoop per day to assess how your body responds. If you feel comfortable with the effects, you can gradually increase the dosage to 2 scoops per day.
2. Typical Dose Ranges
3. How to Take It
   TMG is water-soluble, so it can be easily mixed with water or added to a water-based beverage. You can mix it with a drop of water and consume directly, or add it to a smoothie, shake, or juice for easy intake.
4. When to Take It
   TMG can be taken at any time of day, but it is typically most effective when taken in the morning or early afternoon to support overall well-being. If you are taking 2 scoops per day, splitting the dose between morning and evening can help provide more consistent support.

In summary, 1 scoop per day (590mg) is typically sufficient for general health, while 2 scoops per day may be ideal for those seeking enhanced support for energy production, cognitive function, and overall vitality. Since TMG is water-soluble, it can be mixed with water or a water-based beverage. Start with a lower dose and monitor your body's response before adjusting the dosage.

Store TMG in a cool, dry place, away from direct sunlight, heat, and moisture. Always ensure the resealable pouch is fully sealed after each use to maintain the powder’s quality and potency.